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In preclinical studies in rats and dogs, renagel hydrochloride, which contains the same active moiety as renagel carbonate, reduced vitamins d, e, and k coagulation parameters and folic acid levels at doses of 6 10 times the recommended human dose.

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Information about Renagel.

Renagel must not be used in people with hypophosphataemialow blood phosphate levelsor with bowel obstructiona blockage in the gut

PregnancyNot absorbed systemically following oral administration and maternal use not expected to result in fetal exposure to the drug.

Renagel alone is not indicated for the control of hyperparathyroidismIn patients with secondary hyperparathyroidism Renagel should be used within the context of a multiple therapeutic approachwhich could include calcium supplements1,25-dihydroxy Vitamin D 3 or one of its analogues to lower the intact parathyroid hormoneiPTHlevels.

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renagel revenues are expected to double again in 2001 and within five years to exceed 500 million.

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